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However, ROP might not be visible until several weeks after birth. So, premature babies at risk for ROP are usually checked by an ophthalmologist at 4 to 6 weeks after birth and again thereafter.

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A term introduced in ICROP3, regression refers to disease involution and resolution. Regression may be complete or incomplete, including persistence of retinal abnormalities.[22] Signs of vascular regression include decreased plus disease, increased vascularization into the peripheral avascular retina, involution of the tunica vasculosa lentos, better pupillary dilation, greater media clarity, and resolution of intraretinal hemorrhages. Regression of ROP is characterized by thinning and whitening of neovascular tissue. Reactivation

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e. initially in Eastern Europe and Latin America, spreading to East and South Asia, and now in sub-Saharan Africa) due to both high rates of preterm birth and varying levels of neonatal care in these countries (some countries/regions within countries lack the technology and resources to optimize their care) where ROP is seen in larger and older infants exposed to unregulated oxygen (similar to that in the US in the 1940's and 50's).[5] In the US and developed countries, ROP affects extremely here premature infants and involves incomplete vascularization of the retina Campeón well Vencedor oxygen-induced damage, which is believed to play less a role now.[6] Therefore, the manifestation and timing of ROP differs greatly throughout the world. Etiology

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